Deutsch 
English
EASTMAN™ CAB
- When cellulose is esterified with both acetyl and butyryl radicals to form the mixed ester,
cellulose acetate butyrate, many of the desirable properties of both esters are obtained.
EASTMAN™ CAB 171-15 NF cellaburate, can be used as coating material as the semi-permeable membrane for osmotic drug delivery. It is also used for taste-masking and sustained release
tableting. EASTMAN™ CAB 171-15 NF is made under cGMP and meets the requirements of the National Formulary (NF) and is the subject of U.S. Drug Master File 15490. It is available in powder form.
Sustained Release Through Permeable Membranes
The osmotic pump drug delivery technology typifies sustained release that capitalizes on the nature
of EASTMAN™ CAB films - insoluble yet semipermeable - to allow water to pass through a tablet coating. An
osmotic agent that swells absorbs the water, forcing the active out through a hole drilled in the film.
The same effect can also be achieved by employing water-soluble materials, e.g. hydrophilic plasticizers
like PEG 400 or TEC, in the film to increase the drug’s ability to diffuse through it. EASTMAN™ CAB 171-15 NF is less hydrophilic and has a higher viscosity compared to the two pharmaceutical grades of
EASTMAN™ CA. At the same time EASTMAN™ CAB 171-15 NF films are slightly more flexible. One can tailor the permeability
of a coating film between EASTMAN™ CA and EASTMAN™ CAB by adjusting the ratio of CA to EASTMAN™ CAB in the coating formulation.
Sustained Release by Direct Compression
EASTMAN™ CAB 171-15 NF can be used as matrix for sustained release formulations from direct-compression. The methodology employed consisted of mixing plasticizer, if any, with EASTMAN™ CAB 171-15 NF followed
by incorporation of the active with additional mixing. On one hand, the release rate can be adjusted
by the ratio of active to polymer, on the other hand by the addition of plasticizers. Interestingly,
EASTMAN™ CAB shows, unlike EASTMAN™ CA, a release profile that is dependent on the compression force. Higher compression force leads to slower release rate.
Solid Dispersions
Another application for EASTMAN™ CAB is the use in solid dispersions to obtain a sustained release
profile for poorly soluble drugs. Because of its hydrophobicity EASTMAN™ CAB has good solubilising properties, but swells only slightly in water. It should only be used in combination with other polymers or a sufficient amount of plasticizers in solid dispersions.
Packing and storage
| Packing | 50 kg fiber drum with inner PE-lining |
| Shelf life | 5 years |
| Storage | At ambient temperature, protected from moisture. |
Identifier
| CAS-No.: | 9004-36-8 |
| INCI: | Cellulose Acetate Butyrate |
Material Safety Data Sheet for EASTMAN™ CAB
 | EASTMAN™ CAB Data Sheet |
Further product information can also be found via the following link:
| EASTMAN™ CAB-171-15NF |
You are also welcome to contact us directly at any time.
